Chronic low-grade inflammation is now understood to be one of the central drivers of biological aging, a phenomenon researchers call inflammaging. Rising CRP levels with age are linked to muscle loss, bone thinning, skin deterioration, and shortened lifespan. The good news is that inflammation is not a fixed consequence of getting older. This collection of articles covers the science of how inflammation shapes the aging process and what the evidence says about slowing it down.
Chronic inflammation is one of the central drivers of biological aging, a process researchers call inflammaging. As we age, baseline inflammatory markers like CRP and IL-6 rise even without infection, accelerating muscle loss, bone thinning, skin aging, and shortening lifespan. Inflammaging is not fixed. Exercise, caloric moderation, sleep, and gut health measurably slow it, and tracking CRP over time shows whether your strategies are working.
The foundational overview of inflammaging, covering senescent cells, immune dysregulation, and the CRP patterns seen in centenarians.
ConditionsHow inflammatory cytokines break down muscle tissue faster than it can be rebuilt, and what resistance training does to counter this.
ConditionsChronic inflammation tips the balance between bone-building osteoblasts and bone-resorbing osteoclasts, accelerating age-related bone density loss.
ScienceInflammatory signals degrade collagen, impair the skin barrier, and accelerate visible aging well beyond what sun exposure alone explains.
ScienceResearch on Blue Zone populations and centenarian cohorts consistently identifies low inflammatory markers as a key shared trait.
ScienceDamaged mitochondria release signals that trigger systemic inflammation, linking cellular energy decline directly to the inflammaging process.
ScienceThe body's cellular recycling system removes the damaged proteins and organelles that accumulate with age and drive chronic inflammation.
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